BESS FROST, Ph.D.

Bess Frost is a Bartell Zachry Distinguished Professor in Neurodegenerative Disorders at the Sam & Ann Barshop Institute for Longevity and Aging Studies, the Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Disorders, and Department of Cell Systems & Anatomy at the University of Texas Health San Antonio. Her research revolves around the basic neurobiology connecting toxic forms of tau to neuronal death and dysfunction. The Frost laboratory has discovered that the detrimental effects of pathogenic tau on nuclear and genomic architecture activate retrotransposons and alter RNA metabolism. Through this work, they have identified multiple new targets for therapeutic development, as well as compounds that interfere with these processes and suppress tau-induced neurotoxicity.