Our Consortium Publications
The BNDC is dedicated to funding innovative foundational basic science.
Here are selected key publications that highlight the BNDC’s impact:
2024
Proteomic profiling of interferon-responsive reactive astrocytes in rodent and human.
Prakash P, Erdjument-Bromage H, O'Dea MR, Munson CN, Labib D, Fossati V, Neubert TA, Liddelow SA. Glia. 2024 72(3):625-642. PMID: 38031883.
Multisensory gamma stimulation promotes glymphatic clearance of amyloid
Nature. Murdock, M.H., Yang, CY., Sun, N. et al. 2024 627, 149–156. https://doi.org/10.1038/s41586-024-07132-6
Nanoparticle-Mediated Delivery of Anti-PU.1 siRNA via Localized Intracisternal Administration Reduces Neuroinflammation
Ralvenius WT, Andresen JL, Huston MM, Penney J, Bonner JM, Fenton OS, Langer R, Tsai LH. Adv Mater. 2024 Feb;36(8):e2309225. doi: 10.1002/adma.202309225. Epub 2023 Dec 8. PMID: 38018280.
Novel avenues of tau research.
Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MB, Clelland CD, Cohen AD, Crary JF, Dage JL, Diaz K, Frost B, Gan L, Goate AM, Golbe LI, Hansson O, Karch CM, Kolb HC, La Joie R, Lee SE, Matallana D, Miller BL, Onyike CU, Quiroz YT, Rexach JE, Rohrer JD, Rommel A, Sadri-Vakili G, Schindler SE, Schneider JA, Sperling RA, Teunissen CE, Weninger SC, Worley SL, Zheng H, Carrillo MC. Alzheimers Dement. 2024 Jan 3. doi: 10.1002/alz.13533. Online ahead of print. PMID: 38170841
Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease.
Vance JM, Farrer LA, Huang Y, Cruchaga C, Hyman BT, Pericak-Vance MA, Goate AM, Greicius MD, Griswold AJ, Haines JL, Tcw J, Schellenberg GD, Tsai LH, Herz J, Holtzman DM. Ann Neurol. 2024 Jan 5. doi: 10.1002/ana.26864. Online ahead of print. PMID: 38180638
Wang L, Nykänen NP, Western D, Gorijala P, Timsina J, Li F, Wang Z, Ali M, Yang C, Liu M, Brock W, Marquié M, Boada M, Alvarez I, Aguilar M, Pastor P, Ruiz A, Puerta R, Orellana A, Rutledge J, Oh H, Greicius MD, Le Guen Y, Perrin RJ, Wyss-Coray T, Jefferson A, Hohman TJ, Graff-Radford N, Mori H, Goate A, Levin J, Sung YJ, Cruchaga C. Mol Neurodegener. 2024 Jan 3;19(1):1. doi: 10.1186/s13024-023-00687-4.PMID: 38172904
2023
The complex genetic architecture of Alzheimer's disease: novel insights and future directions.
Andrews SJ, Renton AE, Fulton-Howard B, Podlesny-Drabiniok A, Marcora E, Goate AM. EBioMedicine. 2023 Apr;90:104511. doi: 10.1016/j.ebiom.2023.104511. Epub 2023 Mar 10.PMID: 36907103
Moesin is an effector of tau-induced actin over stabilization, cell cycle activation, and neurotoxicity in Alzheimer's disease.
Beckmann A, Ramirez P, Games M, Bieniek KF, Ray WJ, Frost B iScience. 2023 26(3): 106152. PMID: PMC9984563
Audiovisual gamma stimulation for the treatment of neurodegeneration.
Blanco-Duque C, Chan D, Kahn MC, Murdock MH, Tsai LH. J Intern Med. 2024 Feb;295(2):146-170. doi: 10.1111/joim.13755. Epub 2023 Dec 19. PMID: 38115692; PMCID: PMC10842797.
Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer’s disease.
Castranio EL*, Hasel P*, Haure-Mirande JV, Ramirez Jimenez AV, Hamilton BW, Kim RD, Glabe CG, Wang M, Zhang B, Gandy S, Liddelow SA#, Ehrlich ME#. Alzheimers Dement. 2023 19(6):2239-2252. PMID: 36448627.
Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols.
Frazel PW, Labib D, Fisher T, Brosh R, Pirjanian N, Marchildon A, Boeke JD, Fossati V, Liddelow SA. Nat Neurosci. 2023 26(10):1726-1738. PMID: 37697111.
Single-cell analysis of the nervous system at small and large scales with instant partitions.
Frazel P, Fricano-Kugler C, May-Zhang AA, O'Dea MR, Prakash P, Desmet N, Lee H, Meltzer RH, Fontanez K, Hettige P, Lithwick-Yanai G, Lipson D, Luikart BW, Dasen JS, Liddelow SA. bioRxiv 2023.07.14.549051.
Long-read RNA-seq atlas of novel microglia isoforms elucidates disease-associated genetic regulation of splicing.
Humphrey J, Brophy E, Kosoy R, Zeng B, Coccia E, Mattei D, Ravi A, Efthymiou AG, Navarro E, Muller BZ, Snijders GJ, Allan A, Münch A, Kitata RB, Kleopoulos SP, Argyriou S, Shao Z, Francoeur N, Tsai CF, Gritsenko MA, Monroe ME, Paurus VL, Weitz KK, Shi T, Sebra R, Liu T, de Witte LD, Goate AM, Bennett DA, Haroutunian V, Hoffman GE, Fullard JF, Roussos P, Raj T. edRxiv. 2023 Dec 1:2023.12.01.23299073. doi: 10.1101/2023.12.01.23299073. Preprint. PMID: 38076956
APOE and immunity: Research highlights.
Kloske CM, Barnum CJ, Batista AF, Bradshaw EM, Brickman AM, Bu G, Dennison J, Gearon MD, Goate AM, Haass C, Heneka MT, Hu WT, Huggins LKL, Jones NS, Koldamova R, Lemere CA, Liddelow SA, Marcora E, Marsh SE, Nielsen HM, Petersen KK, Petersen M, Piña-Escudero SD, Qiu WQ, Quiroz YT, Reiman E, Sexton C, Tansey MG, Tcw J, Teunissen CE, Tijms BM, van der Kant R, Wallings R, Weninger SC, Wharton W, Wilcock DM, Wishard TJ, Worley SL, Zetterberg H, Carrillo MC. Alzheimers Dement. 2023 Jun;19(6):2677-2696. doi: 10.1002/alz.13020. Epub 2023 Mar 28.PMID: 36975090 Review.
Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy.
Le K, Soth MJ, Cross JB, Liu G, Ray WJ, Ma J, Goodwani SG, Acton PJ, Buggia-Prevot V, Akkermans O, Barker J, Conner ML, Jiang Y, Liu Z, McEwan P, Warner-Schmidt J, Xu A, Zebisch M, Heijnen CJ, Abrahams B, Jones P. J Med Chem. 2023 Jul 27;66(14):9954-9971. doi: 10.1021/acs.jmedchem.3c00788. Epub 2023 Jul 12. PMID: 37436942.
Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology.
Mathys H, Peng Z, Boix CA, Victor MB, Leary N, Babu S, Abdelhady G, Jiang X, Ng AP, Ghafari K, Kunisky AK, Mantero J, Galani K, Lohia VN, Fortier GE, Lotfi Y, Ivey J, Brown HP, Patel PR, Chakraborty N, Beaudway JI, Imhoff EJ, Keeler CF, McChesney MM, Patel HH, Patel SP, Thai MT, Bennett DA, Kellis M, Tsai LH. Cell. 2023 Sep 28;186(20):4365-4385.e27. doi: 10.1016/j.cell.2023.08.039. PMID: 37774677; PMCID: PMC10601493.
Insights into Alzheimer's disease from single-cell genomic approaches.
Murdock MH, Tsai LH. Nat Neurosci. 2023 Feb;26(2):181-195. doi: 10.1038/s41593-022-01222-2. Epub 2023 Jan 2. PMID: 36593328; PMCID: PMC10155598.
Pathogenic tau–induced transposable element–derived dsRNA drives neuroinflammation.
Ochoa E, Ramirez P, Gonzalez E, De Mange J, Ray WJ, Bieniek Kevin J, Frost B Science Advances. 2023 Jan 6;9(1):eabq5423. doi: 10.1126/sciadv.abq5423. Epub 2023 Jan 6. PMID: 36608133; PMCID: PMC9821943.
The role of reactive astrocytes in inflammation and neurodegeneration. Nat Rev Neurol.
Patani R, Hardingham G, Liddelow SA 2023 19:395-409. PMID: 37308616.
Pathogenic tau decreases nuclear tension in cultured neurons.
Sohn C, Ma J, Ray WJ, Frost B. Front Aging. 2023 Jan 23;4:1058968. doi: 10.3389/fragi.2023.1058968. PMID: 36756194; PMCID: PMC9901542.
Human microglial state dynamics in Alzheimer's disease progression.
Sun N, Victor MB, Park YP, Xiong X, Scannail AN, Leary N, Prosper S, Viswanathan S, Luna X, Boix CA, James BT, Tanigawa Y, Galani K, Mathys H, Jiang X, Ng AP, Bennett DA, Tsai LH, Kellis M. Cell. 2023 Sep 28;186(20):4386-4403.e29. doi: 10.1016/j.cell.2023.08.037. PMID: 37774678; PMCID: PMC10644954.
A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation.
Ralvenius WT, Mungenast AE, Woolf H, Huston MM, Gillingham TZ, Godin SK, Penney J, Cam HP, Gao F, Fernandez CG, Czako B, Lightfoot Y, Ray WJ, Beckmann A, Goate AM, Marcora E, Romero-Molina C, Ayata P, Schaefer A, Gjoneska E, Tsai LH. J Exp Med. 2023 Nov 6;220(11):e20222105. doi: 10.1084/jem.20222105. Epub 2023 Aug 29. PMID: 37642942; PMCID: PMC10465325.
2022
Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration.
Adaikkan C, Wang J, Abdelaal K, Middleton SJ, Bozzelli PL, Wickersham IR, McHugh TJ, Tsai LH. Neuron. 2022 Oct 5;110(19):3091-3105.e9. doi: 10.1016/j.neuron.2022.07.023. Epub 2022 Aug 19. PMID: 35987206; PMCID: PMC9547933.
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes.
Blanchard, J.W., Akay, L.A., Davila-Velderrain, J. et al. Nature, 2022 611, 769–779. https://doi.org/10.1038/s41586-022-05439-w.
Gamma frequency sensory stimulation in mild probable Alzheimer's dementia patients: Results of feasibility and pilot studies.
Chan D, Suk HJ, Jackson BL, Milman NP, Stark D, Klerman EB, Kitchener E, Fernandez Avalos VS, de Weck G, Banerjee A, Beach SD, Blanchard J, Stearns C, Boes AD, Uitermarkt B, Gander P, Howard M 3rd, Sternberg EJ, Nieto-Castanon A, Anteraper S, Whitfield-Gabrieli S, Brown EN, Boyden ES, Dickerson BC, Tsai LH. PLoS One. 2022 Dec 1;17(12):e0278412. doi: 10.1371/journal.pone.0278412. PMID: 36454969; PMCID: PMC9714926.
Melanoma-secreted amyloid beta suppresses neuroinflammation and promotes brain metastasis.
Kleffman K, Levinson G, Rose IVL, Blumenberg LM, Shadaloey SAA, Dhabaria A, Wong E, Galan-Echevarria F, Karz A, Argibay D, Von Itter R, Floristan A, Baptiste G, Eskow NM, Tranos JA, Chen J, Vega Y Saenz de Miera EC, Call M, Rogers R, Jour G, Wadghiri YZ, Osman I, Li YM, Mathews P, DeMattos R, Ueberheide B, Ruggles KV, Liddelow SA, Schneider RJ, Hernando E Cancer Discov. 2022 12(5):1314-1335. PMID: 35262173.
Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system.
Ramirez P, Sun W, Zuniga G, Ochoa E, DeVos S, Hyman B, Chiu G, Roy ER, Orr M, Bugga-Prevot V, Ray WJ, Frost B Progress in Neurobiology. 2022 208: 102181. PMID: 34670118.
Microglial efferocytosis: Diving into the Alzheimer's disease gene pool.
Romero-Molina C, Garretti F, Andrews SJ, Marcora E, Goate AM. Neuron. 2022 Nov 2;110(21):3513-3533. doi: 10.1016/j.neuron.2022.10.015.PMID: 36327897.
Sadick JS*, O'Dea MR*, Hasel P, Dykstra T, Faustin A, Liddelow SA Neuron. 2022 110(11):1788-1805. PMID: 35381189.
Revealing nanostructures in brain tissue via protein decrowding by iterative expansion microscopy.
Sarkar D, Kang J, Wassie AT, Schroeder ME, Peng Z, Tarr TB, Tang AH, Niederst ED, Young JZ, Su H, Park D, Yin P, Tsai LH, Blanpied TA, Boyden ES. Nat Biomed Eng. 2022 Sep;6(9):1057-1073. doi: 10.1038/s41551-022-00912-3. Epub 2022 Aug 29. PMID: 36038771; PMCID: PMC9551354.
Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity.
Victor MB, Leary N, Luna X, Meharena HS, Scannail AN, Bozzelli PL, Samaan G, Murdock MH, von Maydell D, Effenberger AH, Cerit O, Wen HL, Liu L, Welch G, Bonner M, Tsai LH. Cell Stem Cell. 2022 Aug 4;29(8):1197-1212.e8. doi: 10.1016/j.stem.2022.07.005. PMID: 35931030; PMCID: PMC9623845.
Solving neurodegeneration: common mechanisms and strategies for new treatments.
Wareham L, Liddelow SA, Temple S, Benowitz LI, Di Polo A, Wellington C, Goldberg J, He Z, Duan X, Bu G, Davis AA, Shekhar K, La Torre A, Chang DC, Canto-Soler MV, Flanagan JG, Subramanian P, Rossi S, Brunner T, Bovenkamp DE, Calkins DJ. Mol Neurodegen. 2022 17(1):23. PMID: 35313950.